Expression of microsomal triglyceride transfer protein in lipoprotein-synthesizing tissues of the developing chicken embryo
نویسندگان
چکیده
منابع مشابه
Multiple functions of microsomal triglyceride transfer protein
Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles. Its role as an essential chaperone for the biosynthesis of apolipoprotein B (apoB)-containing triglyceride-rich lipoproteins was established after the realization that abetalipoproteinemia patients carry mutations in the MTTP gene resu...
متن کاملMicrosomal triglyceride transfer protein: a multifunctional protein.
Microsomal triglyceride transfer protein (MTP) is a heterodimeric protein that transfers neutral lipids between membranes in vitro. Absence of this lipid transfer activity in the microsomes of abetalipoproteinemia patients established its pivotal function in lipoprotein assembly. Recent studies indicate that the lipid transfer activity is involved in importing triglycerides into the lumen of th...
متن کاملMicrosomal triglyceride transfer protein expression during mouse development.
Feto-maternal transfer of lipophilic nutrients is an important factor in the normal development of the fetus and may be mediated by lipoproteins as carriers of these nutrients. Two proteins that may be important in this process are apolipoprotein B (apoB, the major structural protein of secreted lipoproteins) and microsomal triglyceride transfer protein (MTP) whose normal activity is required f...
متن کاملThe role of microsomal triglyceride transfer protein in lipoprotein assembly: an update.
The discovery of the role of MTP in mediating lipid transfer to apoB has greatly expanded our knowledge of the molecular mechanisms involved in apoB-containing lipoprotein assembly. In this review, advances referring to the structure, regulation and function of MTP are summarized and discussed. In addition to the well-known lipid transfer activity function, MTP has been shown to physically inte...
متن کاملDiscovery of Novel Splice Variants and Regulatory Mechanisms for Microsomal Triglyceride Transfer Protein in Human Tissues
Microsomal triglyceride transfer protein (MTP) is a unique lipid transfer protein essential for the assembly of triglyceride-rich lipoproteins by the liver and intestine. Previous studies in mice identified a splice variant of MTP with an alternate first exon. Splice variants of human MTP have not been reported. Using PCR approaches we have identified two splice variants in human tissues, which...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimie
سال: 2014
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2013.12.020